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Hypothyroidism is incredibly common, especially in women, yet it often goes undiagnosed or undertreated. In my naturopathic practice here in Oregon, I regularly work with women who are experiencing symptoms like fatigue, weight changes, low mood, or brain fog—only to find their thyroid hasn’t been fully evaluated. It's a reminder that we need to take a closer, more thorough look at thyroid health and how it impacts women throughout their lives.


Hypothyroidism Is Common—But Often Missed

An estimated 1 in 8 women will develop thyroid problems during her lifetime, with hypothyroidism being the most common diagnosis. This condition becomes increasingly prevalent with age and is especially common during major hormonal transitions such as postpartum, perimenopause, and menopause. Autoimmune thyroid disease, specifically Hashimoto’s thyroiditis, is the most common cause in developed countries—yet it is still routinely overlooked.


The Limits of Conventional Testing

Most conventional screenings for hypothyroidism rely solely on measuring TSH (thyroid stimulating hormone). While TSH is useful, it’s only one piece of the puzzle. A more thorough assessment includes checking:


  • Free T4 (thyroxine) – the storage form of thyroid hormone

  • Free T3 (triiodothyronine) – the active form that powers metabolism and mood

  • Thyroid antibodies (TPO and TgAb) – to detect autoimmune causes like Hashimoto’s


Without looking beyond TSH, many women are told their thyroid is “normal” even though their symptoms—fatigue, weight gain, brain fog, cold intolerance, hair thinning—tell a different story.


"Normal" Isn’t Always Optimal

Another critical issue is the use of wide, outdated TSH reference ranges. A TSH of 4.0 or 5.0 might be technically normal, but in my clinical experience, many women feel best when their TSH is between 1.0 and 2.0. Optimizing thyroid levels isn’t just about hitting lab numbers—it’s about how you actually feel.


Treatment: One Size Doesn’t Fit All

Most conventional care relies solely on levothyroxine (T4-only medication), but this approach doesn’t work for everyone. Many patients feel better on combination therapies that include T3—either as compounded prescriptions or naturally derived options like Armour Thyroid or NP Thyroid. Unfortunately, these aren’t typically offered unless a patient seeks care outside the standard system. The pros and cons aren't even discussed.


A Holistic, Root-Cause Approach

In my Oregon-based naturopathic practice, I take an integrative approach to thyroid care that includes:

  • Targeted nutrition – Supporting thyroid hormone production and conversion with nutrients like iodine, selenium, zinc, tyrosine, and iron

  • Herbal medicine – Using plant-based therapies to support T4-to-T3 conversion or calm autoimmune inflammation

  • Dietary changes – Reducing inflammatory triggers and supporting gut health

  • Stress and adrenal support – Since chronic stress impairs thyroid function and conversion

  • Pharmaceuticals when needed - Along with education on risks/benefits of the options available.

Every woman’s thyroid story is unique. Managing hypothyroidism is not just a protocol—it’s an art that requires personalized care, comprehensive lab assessment, and a willingness to go beyond the basics.


You Don’t Have to Settle for “Normal”

If you’ve been told your labs are fine but still don’t feel like yourself, you're not alone—and you're not crazy. Hypothyroidism is an epidemic hiding in plain sight, and there are effective ways to uncover and treat the root causes.

If you're in Oregon or the Portland area and are seeking a more thorough, holistic approach to thyroid health, I invite you to reach out. You deserve to feel vibrant, clear, and energized—and it starts with getting the full picture.


"This blog post is for informational purposes only and is not intended to diagnose, treat, or replace medical advice from your healthcare provider. Always consult with your physician or a qualified healthcare professional before

making any changes to your medication, treatment plan, or health regimen."

 
 
 


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Over 9 million Americans are now using GLP-1 medications, and not just for weight loss. From PCOS to menopause, the benefits are changing the way we think about metabolic and hormonal health.


GLP-1 receptor agonists like Semaglutide (Ozempic, Wegovy) and Tirzepatide (Mounjaro, Zepbound) have revolutionized the weight loss and diabetes treatment landscape. But their benefits may go far beyond shedding pounds. These medications offer customized solutions for a variety of conditions, helping individuals manage hormonal imbalances, reduce inflammation, and even support brain health. If you've been considering GLP-1 therapy for weight loss, you may be surprised to learn about its outside-of-the-box benefits.


PCOS: Addressing the Root Cause, Not Just the Symptoms

Polycystic Ovary Syndrome (PCOS) is increasingly recognized as a metabolic disorder rather than just a reproductive condition. Many experts believe that insulin resistance triggers the hormonal imbalances seen in PCOS. This is where GLP-1 medications come in.


How GLP-1’s Help PCOS

  • Increases insulin sensitivity, reducing blood sugar spikes and lowering the risk of Type 2 diabetes.

  • May encourage ovulation and regular menstrual cycles, improving fertility and cycle predictability.

  • Reduces food noise and cravings, making weight management easier.

  • Indirectly lowers androgens, which can improve acne, hair loss, and hirsutism.

  • Supports heart health by reducing cholesterol, blood pressure, and inflammation.

  • Potential neuroprotective benefits, including mood stabilization and cognitive function improvements.


For PCOS patients who struggle with weight gain and difficulty losing weight—even with diet and exercise—GLP-1 therapy can be a game changer.


Menopause: Tackling Weight Gain, Insulin Resistance & Brain Fog

Menopause brings hormonal shifts that slow metabolism, increase fat storage, and raise the risk of insulin resistance. These factors make weight loss frustratingly difficult. GLP-1 medications can offer relief by targeting key metabolic pathways.


How GLP-1’s Help in Menopause

  • Reduces menopausal weight gain by slowing gastric emptying and curbing cravings.

  • Improves insulin sensitivity, lowering the risk of diabetes.

  • Supports cardiovascular health, reducing cholesterol and blood pressure.

  • Helps prevent fatty liver disease, a condition more common post-menopause.

  • Neuroprotection: Emerging research suggests a possible role in reducing Alzheimer’s and cognitive decline, I'm excited to see the studies unfold over time.


For women navigating weight gain and metabolic changes during menopause, GLP-1 therapy may be an effective, science-backed solution.


Hypothyroidism and Hashimoto's: A Potential Ally for Metabolic and Cognitive Health

For individuals with hypothyroidism and Hashimoto’s thyroiditis, managing weight, energy levels, and overall well-being can be a persistent challenge. While GLP-1 receptor agonists (Semaglutide, Liraglutide, Dulaglutide) are not traditionally prescribed for thyroid disorders, emerging research suggests they may offer valuable support for metabolism, inflammation, and cognitive function.


How GLP-1’s Help Hypothyroidism

  • Supporting metabolism and assisting with weight loss

  • Possibly improving focus and concentration, reducing brain fog.

  • Lowering inflammatory cytokines, potentially helping to ease Hashimoto’s symptoms

  • Enhancing digestion and gut health, which can be impacted by hypothyroidism


Inflammation & Autoimmune Conditions: The Anti-Inflammatory Side of GLP-1’s

Chronic inflammation plays a role in autoimmune diseases, arthritis, and even brain fog. GLP-1 medications may help by lowering inflammatory markers like TNF-α, IL-6, and IL-1.


How GLP-1’s Reduces Inflammation

  • Lowers systemic inflammation, possibly reducing pain and swelling in conditions like rheumatoid arthritis and lupus.

  • Supports gut health, potentially benefiting those with inflammatory bowel diseases.

  • Reduces neuroinflammation, improving symptoms like brain fog and cognitive dysfunction in autoimmune conditions.


For individuals struggling with inflammatory disorders, GLP-1 medications may provide relief beyond blood sugar control.


The Future of GLP-1: A Customized Approach

While originally developed for diabetes, GLP-1 receptor agonists are proving to be powerful tools for hormone balance, brain health, and inflammation reduction. As more research emerges, these medications could become a customized solution for those seeking holistic health benefits beyond weight loss.


Customized Dosing & A Holistic Approach

GLP-1 therapy isn't a one-size-fits-all solution. Patients should be offered a tailored approach based on their unique metabolic and hormonal needs. Many may even benefit from microdosing strategies. My priority is to optimize treatment by using the lowest effective dose, maximizing benefits while minimizing risks and side effects. This is especially crucial for GLP-1 medications, where standard aggressive dosing often leads to unwanted effects and increased risks. A holistic treatment plan should include more than just medication—focusing on overall health, diet, exercise, and lifestyle modifications is essential for long-term success and safety.


If you're considering customized GLP-1 therapy in Portland (or anywhere in Oregon) seek out a provider who offers a personalized approach that aligns with your unique needs and health goals.


Key Takeaways:


PCOS: Improves insulin resistance, and indirectly regulates cycles/reduces androgens, and aids weight loss.

Menopause: Supports weight management, reduces insulin resistance, and may protect brain health.

Inflammation & Autoimmune Conditions: Lowers inflammatory markers, reduces pain, and supports cognitive function.

Hypothyroidism: Boost metabolism, lowers inflammation, and supports cognitive function (and possibly mood).

Customized Dosing: individualized treatment plans can enhance effectiveness while reducing risks.

Holistic Approach: GLP-1 therapy works best when combined with a comprehensive health strategy.


Have you seen benefits from GLP-1 therapies for a condition beyond weight loss? Share your experience in the comments!


***This blog post is intended for educational and informational purposes only and does not constitute medical advice. GLP-1 medications are not FDA approved for many of the above medical conditions. Always consult a qualified healthcare professional regarding your personal health and medical decisions.***


 
 
 


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While research shows stress touches every part of our bodies and brains, it is often brushed over or completely ignored in your doctor’s office. 


When we perceive stress, it immediately thrusts our nervous systems into the chemical cascade that triggers sympathetic nervous system mode (think fight, flight, freeze). Our bodies get flooded with neurotransmitters that make us hyper-vigilant. Our digestion shuts down as blood flow is shunted away from non-essential areas. Our muscles become tense as vessels constrict. Inflammation increases while immune function decreases. Our focus and memory centers function poorly as the survival brain takes over. Our moods become dysregulated as we prepare for the worst. 


Signs you’re dealing with a chronic stress response. 


  • You have chronic indigestion or inconsistent bowel movements (loose or constipation).

  • You feel a sense of panic even when things are calm or struggle to regulate your mood.

  • Energy becomes depleted, or you have excess energy signs (insomnia, anxiety, and racing mind). 

  • You struggle with appetite, either in lack of or excess. 

  • You have chronic muscle tension or tension headaches. 


What can be done? 


While none of us can completely eliminate stress from our lives, there is much we can do to lessen its effect on our minds and bodies. 


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  • Movement: move your body in a way you enjoy for 30-45 minutes at least a few times weekly.

  • Sleep: aim for 7-9 hours of sleep per night. Don’t underestimate those sleep hygiene routines here. No screen time 1 hour prior to sleep, limit caffeine after 2-4PM, creating a consistent sleep and wake time diet, etc. 

  • Practice mindfulness: set aside 10-15 minute periods in your day to focus on your breath and allow your mind’s thoughts, impulses, and feelings to pass through you without judgment.

  • Diet: feed your body with nutritious whole foods. Try not to skip meals to keep your blood sugar stable throughout the day. Focus on protein with each meal. Meals are ideally enjoyed at rest for optimal digestion.

  • Lastly, consider what environments, behaviors, habits, situations, and people are creating stress in your life. Some of this is beyond our control, but do what you can to arrange your life to prioritize your health! 


There is never shame in working with a counselor on developing healthy coping skills and boundaries, identifying your triggers, and coming up with strategies to retrain your brain’s protective mechanisms.


Still can’t get to the bottom of your body’s stress responses? 


There are a host of medical conditions that exacerbate feelings of stress and an appropriate workup by your doctor is key here. A thorough investigation should be done to rule out contributing hormone imbalances, adrenal fatigue or excess, thyroid conditions, blood sugar imbalances, and nutrient deficiencies, to name a few. 


The solution between you and your provider should always be as unique as you are to address the root causes of your symptoms. 


For those ready to take matters into their own hands, I have curated a blood analysis panel for women that takes a deep dive into many pathways that can lead to excess stress, anxiety, and dysregulation. I highly encourage you to meet with a provider you trust to help you interpret the results. For established clients/patients, you can receive an additional 40% off of this already heavily discounted lab rate. Message us in our secure portal for more information. 


In Health, Dr. Delia Sewell, ND




 
 
 
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